Effects of Bilateral Deep Brain Stimulation of the Subthalamic Nucleus on Olfactory Function in Parkinson's Disease Patients

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Effects of Bilateral Deep Brain Stimulation of the Subthalamic Nucleus on Olfactory Function in Parkinson's Disease Patients

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Descripción:: The goal of the present study was to evaluate the effects of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on olfaction in patients with Parkinson's disease (PD).

Methods: 15 patients suffering from sporadic PD-related dysosmia were implanted with bilateral electrodes aimed at the STN. One week before the surgery, odor detection threshold (DT) and identification threshold (IT) were evaluated in all patients using the ‘five odor olfactory detection arrays’ in both medication-off and medication-on conditions. 15 healthy age-matched controls also received the same olfactory evaluation. Patient evaluations were repeated at 6 and 12 months postoperatively in a medication-off/stimulator-on or medication-off/stimulator-off condition. Odor DT and IT scores were compared pre- and postoperatively, as well as between the medication-off/stimulator-on or -off conditions
Enviado el:: 13 Jan 2010
Tamaño del archivo:: 147.00 Kb
Descargas:: 1
Autor del archivo:: Xiaodong Guo, Guodong Gao, Xuelian Wang, Lihong Li, Weixin Li, Qinchuan Liang, and Hua Zhang
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