A new transformative approach to defining, studying and treating Parkinson's disease has been revealed by investigators. Rather than approaching Parkinson's disease as a single entity, the international cadre of researchers advocates targeting therapies to distinct 'nodes or clusters' of patients based on specific symptoms or molecular features of their disease.
When monitoring Parkinson's disease, SPECT imaging of the brain is used for acquiring information on the dopamine activity. A new study shows that the dopamine activity observed in SPECT imaging does not reflect the number of dopamine neurons in the substantia nigra, as previously assumed.
Folinic acid can protect neurons in fruit flies, report scientists. The study suggests that folinic acid, which is used in medications to treat bowel cancer, can also protect neurons associated with Parkinson's disease in fruit flies.
Investigators find that a gene variant that produces red hair and fair skin in humans and in mice, which increases the risk of the dangerous skin cancer melanoma, may also contribute to the known association between melanoma and Parkinson's disease.
The toxic protein behind Parkinson’s disease may not spread like an infection from nerve cell to nerve. Instead, say researchers, the protein may simultaneously affect all parts of the nervous system inside and outside of the brain.
Statistics show that 25 per cent of recently diagnosed patients suffered a fall in the first year. That came as a surprise to researchers. They had thought that falls tended to occur during later stages of the disease.
Investigators have discovered a novel link between a protein called SV2C and Parkinson's disease (PD). Prior work had suggested that the SV2C gene was associated with the curious ability of cigarette smoking to reduce PD risk.
New research results are expanding our understanding of the physiological role of the glial cell line-derived neurotrophic factor GDNF in the function of the brain's dopamine systems. In a new article, researchers establish that GDNF is an important physiological regulator of the functioning of the brain’s dopamine neurons.