Unidos contra el Parkinson :: File Repository
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Investigación Parkinson (English)
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Involuntary movements, or dyskinesia, represent a debilitating complication of dopamine replacement therapy for Parkinson disease (PD). The trans...
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27 Feb 2010
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511.61 Kb
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5
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Olivier Berton, Céline Guigoni, Qin Li, Bernard H. Bioulac, Incarnation Aubert, Christian E. Gross,
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The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson Disease (PD) is mounting and becoming increasingly more convinc...
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27 Feb 2010
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169.89 Kb
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3
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Casey Cook and Leonard Petrucelli
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Up-regulation of activity of γ-glutamyl transpeptidase (GGT) has been reported to occur in the Parkinsonian substantia nigra, the area of the brai...
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11 Jan 2010
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223.32 Kb
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0
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Shankar J. Chinta, Jyothi M. Kumar, Hongqiao Zhang, Henry Jay Forman, and Julie K. Andersen
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A reduced risk for Parkinson's disease (PD) among cigarette smokers has been observed consistently during the past 30 years. Recent evidence sugges...
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06 Jan 2010
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61.24 Kb
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1
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Harvey Checkoway, Karen Powers, Terri Smith-Weller, Gary M. Franklin, W. T. Longstreth, Phillip D. S
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We studied the potential neurotrophic effects of the RXR ligand LG100268 (LG268) and the RXR-Nurr1 ligand XCT0139508 (XCT) in neuronal cultures der...
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31 Dec 2009
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302.66 Kb
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1
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- File Author:
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Stina Friling, Maria Bergsland, and Susanna Kjellander
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More than 80 years after iron accumulation was initially described in the substantia nigra (SN) of Parkinson's disease (PD) patients, the mechanism...
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30 Nov 2009
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824.44 Kb
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0
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α-Synuclein (SYN) is the major component of Lewy bodies, the neuropathological hallmarks of Parkinson's disease (PD). Missense mutations and multi...
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02 Jul 2009
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0
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Hui-Ming Gao, Paul T. Kotzbauer, Kunihiro Uryu, Susan Leight, John Q. Trojanowski, and Virginia M.-Y
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While numerous hypotheses have been proposed to explain the molecular mechanisms underlying the pathogenesis of neurodegenerative diseases, the the...
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28 Jun 2009
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0
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Kristen A Malkus, Elpida Tsika, and Harry Ischiropoulos
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Recent pharmacotherapy trials in Parkinson' disease (PD) using dopaminergic neuroimaging as outcome parameter failed to show significant relationsh...
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24 Jun 2009
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3
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- File Author:
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Nicolaas I. Bohnen, MD, PhD, Hiroto Kuwabara, MD, PhD, Gregory M Constantine, PhD, Chester A. Mathis
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Calcium is a key signaling ion involved in many different intracellular and extracellular processes ranging from synaptic activity to cell-cell com...
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02 Jun 2009
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0
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- File Author:
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Philippe Marambaud, Ute Dreses-Werringloer and Valérie Vingtdeux
Striatal overexpression of ΔJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease
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