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Activation of Retinoid X Receptor increases dopamine cell survival in models for Parkinson's disease
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- Description:
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We studied the potential neurotrophic effects of the RXR ligand LG100268 (LG268) and the RXR-Nurr1 ligand XCT0139508 (XCT) in neuronal cultures derived from rat primary vMB and mESCs. RXR ligands protect DA neurons from stress, such as that induced by the PD-modeling toxin 6-hydroxy dopamine (6-OHDA) and hypoxia, but not from stress induced by oxidative hydrogen peroxide (H2O2) or the excitotoxic agent kainic acid (KA). The neurotrophic effect is selective for DA neurons. DA neurons from rat primary vMB and mESCs behaved similarly, but the mESC-derived cultures contained a much higher fraction of DA cells and thus provided more accessible experimental conditions.
- Submitted On:
- 31 Dec 2009
- File Size:
- 302.66 Kb
- Downloads:
- 1
- File Author:
- Stina Friling, Maria Bergsland, and Susanna Kjellander
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