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Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors

Short Description:
The correct identity and functional capacity of transplanted dopamine (DA) neurons derived in vitro from embryonic stem (ES) cells is a critical fa...
Submitted On:
15 Dec 2008
File Size:
429.59 Kb
Downloads:
4
Rating:
Total Votes:0

Strengths and Limitations of Genetic Mouse Models of Parkinson’s Disease

Short Description:
Genetic mouse models based on α-synuclein overexpression are particularly compelling because abnormal accumulation of α-synuclein occurs in spora...
Submitted On:
02 Jan 2009
File Size:
57.65 Kb
Downloads:
5
Rating:
Total Votes:0

Cell systems and the toxic mechanism(s) of α-synuclein

Short Description:
Mutations in the SNCA gene are causal for familial Parkinson disease/Lewy body disease. α-Synuclein is a small acidic protein that binds loosely t...
Submitted On:
02 Jan 2009
File Size:
78.62 Kb
Downloads:
5
Rating:
Total Votes:0

In vivo silencing of alpha-synuclein using naked siRNA

Short Description:
Background Overexpression of α-synuclein (SNCA) in families with multiplication mutations causes parkinsonism and subsequent dementia, characteri...
Submitted On:
02 Jan 2009
File Size:
303.89 Kb
Downloads:
4
Rating:
Total Votes:0

The predictive value of transcranial duplex sonography for the clinical diagnosis in undiagnosed parkinsonian syndromes

Short Description:
Transcranial duplex sonography (TCD) of the substantia nigra has emerged as a promising, non-invasive tool to diagnose idiopathic Parkinson's disea...
Submitted On:
21 Jan 2009
File Size:
240.15 Kb
Downloads:
0
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Complex I Deficiency in Parkinson’s Disease Frontal Cortex

Short Description:
Study of complex I (NADH:ubiquinone oxidoreductase) activity in Parkinson’s disease (PD) brain has identified loss of activity only in substantia...
Submitted On:
21 Jan 2009
File Size:
94.82 Kb
Downloads:
2
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Total Votes:0

Autologous transplants of Adipose-Derived Adult Stromal (ADAS) afford dopaminergic neuroprotection in a model of Parkinson’s disease

Short Description:
Adult adipose contains stromal progenitor cells with neurogenic potential. However, the stability of neuronal phenotypes adopted by Adipose-Derived...
Submitted On:
03 Mar 2009
File Size:
737.10 Kb
Downloads:
0
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Total Votes:0

Dopamine neurons implanted into people with Parkinson’s disease survive without pathology for 14 years

Short Description:
Postmortem analysis of five subjects with Parkinson’s disease9–14 years after transplantation of fetal midbrain cell suspensions revealed survi...
Submitted On:
20 Mar 2009
File Size:
112.85 Kb
Downloads:
3
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Total Votes:0

The Spectrum of Parkinsonian Manifestations Associated With Glucocerebrosidase Mutations

Short Description:
Background—Mutations in the glucocerebrosidase gene (GBA) result in Gaucher disease and can be associated with a phenotype characterized by adult...
Submitted On:
20 Mar 2009
File Size:
53.19 Kb
Downloads:
0
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Total Votes:0

Cross-Study Transcriptional Analysis of Parkinson's Disease

Short Description:
The study of Parkinson's disease (PD), like other complex neurodegenerative disorders, is limited by access to brain tissue from patients with a co...
Submitted On:
25 Mar 2009
File Size:
109.67 Kb
Downloads:
1
Rating:
Total Votes:0
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