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A Critical Evaluation of the Ubiquitin-Proteasome System in Parkinson's Disease
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- Description:
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The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson Disease (PD) is mounting and becoming increasingly more convincing. However, it is presently unclear whether UPS dysfunction is a cause or result of PD pathology, a crucial distinction which impedes both the understanding of disease pathogenesis and the development of effectual therapeutic approaches. Thus recent findings specifically regarding the role of the UPS in PD are discussed within this review, and offer new insight and provide direction for future research to conclusively resolve this debate.
- Submitted On:
- 27 Feb 2010
- File Size:
- 169.89 Kb
- Downloads:
- 3
- File Author:
- Casey Cook and Leonard Petrucelli
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